Interconnected Pathologies: Exploring the Relationship Between Rheumatoid Arthritis and Periodontitis

Vijaya Lakshmi Pavani Kondru

Abstract


Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that share common pathogenic mechanisms and risk factors. Emerging evidence suggests a bidirectional relationship between these two conditions, with RA patients exhibiting a higher prevalence and severity of periodontitis, and periodontal disease exacerbating systemic inflammation and joint destruction in RA. This review explores the intricate interplay between RA and periodontitis, focusing on shared inflammatory pathways, immune dysregulation, and genetic predisposition. Epidemiological studies supporting the association between RA and periodontitis are discussed, along with potential confounders and effect modifiers. Clinical implications for the management of patients with RA-associated periodontitis are highlighted, emphasizing the importance of interdisciplinary collaboration and personalized treatment approaches. Understanding the complex relationship between RA and periodontitis is essential for optimizing patient care and improving outcomes in individuals affected by these chronic inflammatory conditions.


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